The Shapiro syndrome is a rare disorder consisting of paroxysmal hypothermia (due to hypothalamic dysfunction of thermoregulation), epilepsy, and agenesis of the corpus callosum with onset typically on adulthood. The disease affects about 50 people worldwide. The duration and frequency of the episodes vary from person to person, with some episodes lasting hours to weeks and occurring from hours to years. Very little is known about the disease due to the small number of people affected.[1]